Exploring the Brain, Advancing Care

Founded in 2023, the NeuroIMPRINT Lab is led by Dr. Alexandre Boutet (Principal Investigator) and powered by a diverse team of researchers with backgrounds in neuroscience, engineering, physics, and medicine. Our group includes students and trainees at every stage - from undergraduates to postdoctoral fellows - working side by side with clinicians and scientists. This diversity is our strength: it allows us to look at brain science from multiple angles and ensures that our discoveries move quickly from the lab to the clinic. At the heart of our mission is precision medicine - developing imaging tools that help deliver the right treatment to the right patient at the right time.

Research areas

Our primary focus is on neurodegenerative disorders, including movement disorders such as Parkinson’s disease and various forms of dementia. Beyond these conditions, we also collaborate across disciplines to investigate how the brain is affected in other diseases, including ophthalmological disorders.

A major part of our work centers on interventional treatments - particularly deep brain stimulation (DBS) and MR-guided focused ultrasound (MRgFUS) - to understand how these therapies reshape brain networks and to develop tools that optimize outcomes for each patient.

To achieve this, we use state-of-the-art imaging and modeling techniques such as functional MRI (fMRI) and diffusion tractography, combining them with computational approaches to map circuits, predict treatment response, and guide precision medicine.

Main collaborators

At NeuroIMPRINT Lab, our work is strengthened by partnerships with world-class clinicians and scientists:

  • Dr. Andres Lozano – A global pioneer in functional neurosurgery, advancing deep brain stimulation (DBS) for movement and psychiatric disorders.

  • Dr. Anthony Lang – An internationally recognized neurologist, shaping how Parkinson’s disease and movement disorders are treated worldwide.

  • Dr. Alfonso Fasano – A leader in clinical neurology and DBS programming, focused on tailoring therapies to each patient.

  • Dr. Jurgen Germann – An imaging scientist specializing in advanced MRI analysis and machine learning, with unique expertise to help us build predictive biomarkers.

  • Dr. Kamil Uludağ – A renowned physicist developing cutting-edge MRI methods, including ultra–high-field imaging to capture brain networks in greater detail.

  • Dr. Sriranga Kashyap – An imaging physicist with expertise in resting-state fMRI and MRI optimization, advancing imaging methods for neuromodulation research.

  • Dr. Ian Connell – A biomedical engineer with deep expertise in MRI safety for implanted devices, guiding safe translation of new technologies.

  • Dr. Edward Margolin – A neuro-ophthalmologist, bringing key expertise in vision biomarkers and how brain disease affects sight.

Together, these collaborations bridge neurosurgery, neurology, imaging, engineering, and patient care - ensuring that our discoveries move from the lab to the clinic.

Vision and guiding questions

We envision a future where neuroimaging delivers biomarkers that guide care for every patient walking into the clinic. From early disease detection to treatment monitoring, imaging will inform each stage of the journey. Our work is driven by three guiding questions:

  1. Mapping:  How are brain networks organized?

  2. Mechanism:  How are these networks altered in disease?

  3. Medicine:  How can patient-specific data be used to restore abnormal circuits?